People

Principal Investigator

Picture of Ayala Shiber

Ayala Shiber

email:  ayalashiber@technion.ac.il
Phone:  972-778873763
Address:  Emerson, room 3-26
Our main research objective is to resolve the long standing question: How do cells direct their proteome to fold to their native, functional state and avoid misfolding diseases. We are exploring the mechanisms guiding the folding and assembly of newly synthesized proteins into multi-molecular complexes as well as the mechanisms for degradation of “lonely” subunits. We are studying the role of the ribosome as a platform for coordinating complex assembly during synthesis, by advanced techniques combining biochemistry and deep sequencing such as selective ribosome profiling as well as super resolution microscopy. We are also developing tools for studying single molecule mRNA-protein interactions, in vivo.
 

 

Lab Manager & Research associate

Picture of Hagit Bar-Yosef

Hagit Bar-Yosef

Lab Manager & Research associate
email:  hagitby@technion.ac.il
Phone:  972-778873763
Address:  Emerson, room 3-24
Co-translational protein folding ans assembly
 

Students

Picture of Seraj Atarya

Seraj Atarya

M.Sc. student
Phone:  972-778873763
Address:  Emerson, room 3-24
Discovery of assembly-specific degradation factors: A systematic, proteome-wide identification of novel, co-translationally acting degradation factors.
 
Picture of Johannes Venezian

Johannes Venezian

M.Sc. student
Phone:  972-778873763
Address:  Emerson, room 3-24
Evolution of protein folding and assembly pathways: Deciphering the characteristics of divergent co-translational assembly pathways.
 
Picture of Hila Zilberman

Hila Zilberman

Research Assistant
Phone:  972-778873763
Address:  Emerson, room 3-24
CRISPR-Cas9 solutions for improved Cas9 sensitivity